Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatis
نویسندگان
چکیده
The global variations in the gene expression pattern of drug treated (½X) and laboratory evolved drug-resistant strains (2XR and 4XR) of Mycobacterium smegmatis were obtained and compared with the M. smegmatis mc(2) 155 (WT) strain. The genes exhibiting two-fold change and p-value <0.05 under the treated conditions have been considered as differentially expressed genes (DEGs). Overall, the numbers of DEGs observed are 1529 in ½X (596-up, 933-down), 1381 (899-up, 482-down) in 2XR and 716 in 4XR (267-up, 449-down) conditions. The data is publicly available through the GEO database with accession number GSE64132.
منابع مشابه
Complete Genome Sequences of a Mycobacterium smegmatis Laboratory Strain (MC2 155) and Isoniazid-Resistant (4XR1/R2) Mutant Strains
We report the whole genome sequences of a Mycobacterium smegmatis laboratory wild-type strain (MC(2) 155) and mutants (4XR1, 4XR2) resistant to isoniazid. Compared to Mycobacterium smegmatis MC(2) 155 (NC_008596), a widely used strain in laboratory experiments, the MC(2) 155, 4XR1, and 4XR2 strains are 60, 128 and 93 bp longer, respectively.
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2015